Anyone who has ever suffered from jet lag knows you can’t disrupt your normal sleep schedule without physiological effects. New research in lactating dairy cattle demonstrates that changing natural circadian rhythms can cause decreased mammary development and increased insulin resistance, which may lead to lower subsequent milk yield. The research, presented in the Journal of Dairy Science, is helping scientists better understand how circadian and metabolic systems are connected and mutually managed.
“This work indicates that the circadian timing system plays a role in the regulation of glucose homeostasis and mammary development in cattle and shows the importance of minimizing disturbances in day-to-day activities and environment of cattle and maintaining consistency during late gestation to ensure optimal milk production in early lactation,” said author Theresa Casey, PhD, Department of Animal Sciences, Purdue University.
Casey and her colleagues exposed Holstein cows to 16 hours of light and 8 hours of darkness, with the light cycle shifting 6 hours every 3 days, starting 35 days before the animals were expected to calve. After five weeks of exposure, cows in late pregnancy exhibited increased insulin resistance and reduced mammary development compared with the control group. The researchers found that the effects carried over into the postpartum period, after the treatment was eliminated, and cows had reduced milk yield and decreased insulin sensitivity.
Because major shifts occur in how dietary energy is directed to support fetal growth and milk synthesis during the transition from late gestation to early lactation, this is the most metabolically demanding time for dairy cattle. The scientists zeroed in on the levels of blood glucose, insulin, nonesterified fatty acids, and β-hydroxybutyrate, which are the markers for changes in plasma metabolite and hormone levels that reflect physiological changes in response to increased metabolic demands.
Research was supported by the Agriculture and Food Research Initiative competitive grant from the USDA National Institute of Food and Agriculture.
About the Journal of Dairy Science
The Journal of Dairy Science® (JDS), an official journal of the American Dairy Science Association®, is co-published by Elsevier and FASS Inc. for the American Dairy Science Association. It is the leading general dairy research journal in the world. JDS readers represent education, industry, and government agencies in more than 70 countries, with interests in biochemistry, breeding, economics, engineering, environment, food science, genetics, microbiology, nutrition, pathology, physiology, processing, public health, quality assurance, and sanitation. JDS has a 2019 Journal Impact Factor of 3.333 and 5-year Journal Impact Factor of 3.432 according to Journal Citation Reports (Source: Clarivate 2020). www.journalofdairyscience.org
About the American Dairy Science Association (ADSA)
The American Dairy Science Association (ADSA) is an international organization of educators, scientists, and industry representatives who are committed to advancing the dairy industry and keenly aware of the vital role the dairy sciences play in fulfilling the economic, nutritive, and health requirements of the world’s population. It provides leadership in scientific and technical support to sustain and grow the global dairy industry through generation, dissemination, and exchange of information and services. Together, ADSA members have discovered new methods and technologies that have revolutionized the dairy industry. www.adsa.org
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postpartum,” by C.J. McCabe, A. Suarez-Trujillo, K.A. Teeple, T.M. Casey, and J.P. Boerman (https://doi.org/10.3168/jds.2020-19250). It appears in the Journal of Dairy Science, volume 104, issue 2 (February 2021), published by FASS Inc. and Elsevier.
The article is openly available at www.journalofdairyscience.org/article/S0022-0302(20)31040-7/fulltext.